Antityrosinase and antimicrobial activities of 2-phenylethanol, 2-phenylacetaldehyde and 2-phenylacetic acid

作者：Zhu Yu Jing; Zhou Han Tao; Hu Yong Hua; Tang Jian Yang; Su Ming Xing; Guo Yun Ji; Chen Qing Xi; Liu Bo^*

来源：Food Chemistry, 2011, 124(1): 298-302.

DOI：10.1016/j.foodchem.2010.06.036

• 2-Phenylethanol
• 2-Phenylacetaldehyde
• 2-Phenylacetic acid
• Antityrosinase activity
• Antimicrobial activity

The inhibition kinetics of 2-phenylethanol, 2-phenylacetaldehyde and 2-phenylacetic acid on the enzyme activity of mushroom tyrosinase have been investigated. The results showed that these aromatic compounds can lead to reversible inhibition of the enzyme; furthermore, 2-phenylacetaldehyde and 2-phenylacetic acid are uncompetitive inhibitors and 2-phenylethanol is a mixed-type inhibitor. The inhibition constants have been determined and the inhibiting ability was: 2-phenylacetaldehyde > 2-phenylacetic acid > 2-phenylethanol, indicating that the functional group on the benzene ring group played an important role in the inhibition of the enzyme. In addition, 2-phenylacetic acid and 2-phenylethanol were found to have effective antibacterial activities, and 2-phenylacetic acid was more effective against Escherichia coli and Ralstonia solanacearum than 2-phenylethanol, but 2-phenylacetaldehyde lacked of antibacterial activity.

• 出版日期2011-1-1
• 单位厦门大学; 福建省农业科学院