MicroRNA-24-3p regulates Hodgkin's lymphoma cell proliferation, migration and invasion by targeting DEDD

作者：Wang, Jing; Yin, Kai; Lv, Xianping; Yang, Qiankun; Shao, Ming; Liu, Xin; Sun, Hui^*

来源：Oncology Letters, 2019, 17(1): 365-371.

DOI：10.3892/ol.2018.9599

• microRNA-24-3p
• Hodgkin's lymphoma
• proliferation
• migration
• invasion
• DEDD

Hodgkin's lymphoma (HL) is a common hematologic tumor, and the incidence is increasing. At present, it is considered that miRNAs are closely related to HL. Substantial attention has been paid to the effects of miRNA on the pathophysiological process of HL. This study was focused on the potential role of miR-24-3p in HL by targeting DEDD. The reverse transcription-quantitative PCR (RT-qPCR) results demonstrated that miR-24-3p expression was highly elevated and DEDD expression reduced inversely in HL tissues compared to adjacent tissues. According to the results of CKK-8 assays, miR-24-3p was able to accelerate HL cell proliferation. In addition, the results of the Transwell assays also indicated that miR-24-3p promoted the invasion and migration abilities of HL cells. Moreover, the results demonstrated that miR-24-3p inhibited DEDD expression. Hence, the present study revealed that miR-24-3p could accelerate HL development through inhibiting DEDD.

• 出版日期2019-1
• 单位郑州大学