A Degrading View of Regulatory T Cells

作者：Laurence Arian; Belkaid Yasmine; O'Shea John J^*

来源：Immunity, 2013, 39(2): 201-203.

DOI：10.1016/j.immuni.2013.08.017

Studies by van Loosdregt et al. and Chen et al. in this issue of Immunity provide evidence for previously unrecognized players that regulate FOXP3 degradation. These are interesting developments that point to unappreciated mechanisms by which inflammatory signals can impact expression of FOXP3 and possibly the stability of Treg cell phenotypes.

• 出版日期2013-8-22