In vitro selection of electrochemical peptide probes using bioorthogonal tRNA for influenza virus detection

作者:Bahadur Tara K C; Tada Seiichi; Zhu Liping; Uzawa Takanori; Minagawa Noriko; Luo Shyh Chyang; Zhao Haichao; Yu Hsiao hua; Aigaki Toshiro; Ito Yoshihiro*
来源:Chemical Communications, 2018, 54(41): 5201-5204.
DOI:10.1039/c8cc01775a

摘要

An electrosensitive peptide probe has been developed from an in vitro selection technique using biorthogonal tRNA prepared with an electroreactive non-natural amino acid, 3,4-ethylenedioxythiophene-conjugated aminophenylalanine. The selected probe quantitatively detected the influenza virus based on a signal turn-on mechanism. The developed strategy could be used to develop electrochemical biosensors toward a variety of targets.

  • 出版日期2018-5-21
  • 单位RIKEN