A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

作者：Wiseman Frances K; Al Janabi Tamara; Hardy John; Karmiloff Smith Annette; Nizetic Dean; Tybulewicz Victor L J; Fisher Elizabeth M C; Strydom Andre

来源：Nature Reviews Neuroscience, 2015, 16(9): 564-574.

DOI：10.1038/nrn3983

Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP)-an Alzheimer disease risk factor-although the possession of extra copies of other chromosome 21 genes may also play a part. Further study of the mechanisms underlying the development of Alzheimer disease in people with Down syndrome could provide insights into the mechanisms that cause dementia in the general population.

• 出版日期2015-9