Antioxidative activities of histidine containing caffeic acid-dipeptides

作者：Seo Hyo Suk; Kwak Seon Yeong; Lee Yoon Sik^*

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(14): 4266-4272.

DOI：10.1016/j.bmcl.2010.04.135

• Antioxidant
• Caffeic acid
• Caffeic acid-histidine dipeptides
• Antioxidative activity

Antioxidants have been utilized in both the food and cosmetics industries to neutralize the activities of reactive oxygen species (ROS) and free radicals. Histidine-containing peptides are powerful antioxidants that exist in nature. Additionally, hydroxycinnamic acid (HCA)-peptide conjugates exhibit a synergistically enhanced antioxidative activity. Thus, caffeic acid (CA), a natural antioxidant, was conjugated to histidine-containing dipeptides (His dipeptides) in order to develop better antioxidants. The antioxidative activities were measured using 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging test and lipid peroxidation test with ferric thiocyanate method. Some of the CA-His dipeptides exhibited better radical scavenging activities than CA, and all of the CA-His dipeptides showed enhanced lipid peroxidation inhibitory activities. His dipeptide enhanced the antioxidative activity of CA, and the position of histidine also affected the antioxidative activity of the compounds. CA-proline-histidine amide (CA-Pro-His-NH(2)) exhibited the highest activity in both the free radical scavenging test and the lipid peroxidation inhibition test.

• 出版日期2010-7-15