Detection of Single Nanoparticles and Lentiviruses Using Microcavity Resonance Broadening

作者:Shao, Linbo; Jiang, Xue-Feng; Yu, Xiao-Chong; Li, Bei-Bei; Clements, William R.; Vollmer, Frank; Wang, Wei; Xiao, Yun-Feng*; Gong, Qihuang
来源:Advanced Materials, 2013, 25(39): 5616-+.
DOI:10.1002/adma201302572

摘要

A new label-free sensing mechanism is demonstrated experimentally by monitoring the whispering-gallery mode broadening in microcavities. It is immune to both noise from the probe laser and environmental disturbances, and is able to remove the strict requirement for ultra-high-Q mode cavities for sensitive nanoparticle detection. This ability to sense nanoscale objects and biological analytes is particularly crucial for wide applications.