Aminolactone Chiral Modifiers for Heterogeneous Asymmetric Hydrogenation: Corrected Structure of Pantoyl-Naphthylethylamine, In-Situ Hydrogenolysis, and Scanning Tunneling Microscopy Observation of Supramolecular Aminolactone/Substrate Assemblies on Pt(111)

作者：Goubert Guillaume; Demers Carpentier Vincent; Loach Richard P; Lafleur Lambert Raphael; Lemay Jean Christian; Boukouvalas John^*; McBreen Peter H

来源：ACS Catalysis, 2013, 3(12): 2677-2683.

DOI：10.1021/cs4007588

• heterogeneous asymmetric hydrogenation
• scanning tunneling microscopy
• chiral aminolactones
• chemisorbed diastereomeric complexes
• stereostructure reassignment
• pantoylnaphthylethylamine
• ketopantolactone
• Orito reaction

As established by Balker and co-workers, pantoylnaphthylethylamine (PNEA) is an efficient synthetic chiral modifier for the asymmetric hydrogenation of ketopantolactone (KPL) to pantolactone on supported Pt catalysts. We report a scanning tunneling microscopy (STM) study of PNEA and PNEA-derived aminolactone species on Pt(111) and a reassignment of the relative stereochemistry of the modifier. Robust organic chemistry methods were used to establish that the structure of PNEA is R,S rather than R,R. The dissociative chemisorption of a fraction of PNEA adsorbed on Pt(111) yields two fragments that we attribute to a process involving C-N bond scission. We show that C-N bond scission occurs under hydrogenation conditions on PNEA-modified Pt/Al2O3 catalysts, forming the aminolactone amino-4,4-dimethyldihydrofuran-2-one (AF). STM measurements on (S)-AF and 2,2,2-trifluoroacetophenone coadsorbed on Pt(111) show the formation of isolated 1:1 complexes. In contrast, measurements on coadsorbed (S)-AF and KPL show fluxional supramolecular AF/KPL assemblies. The possibility that such assemblies contribute to the overall enantioselectivity observed for PNEA-modified Pt catalysts is discussed.

• 出版日期2013-12