Beyond transitional selection: New roles for BLyS in peripheral tolerance

作者：Oropallo Michael A; Kiefer Kerstin; Marshak Rothstein Ann; Cancro Michael P^*

来源：Drug Development Research, 2011, 72(8): 779-787.

DOI：10.1002/ddr.20487

• BLyS
• BAFF
• B lymphocyte
• autoimmunity
• tolerance
• Toll-like receptors
• Belimumab

B-cell targeted therapies have enjoyed recent success in the treatment of systemic autoimmune diseases. Among these, Belimumab, which blocks the B-cell survival cytokine BLyS, was recently approved for the treatment of systemic lupus erythematosus. It is therefore important to consider the roles BLyS plays in B-cell tolerance. Herein, we review how BLyS contributes to the negative selection of autoreactive B-cell clones from the preimmune repertoire as well as its role in regulating both germinal center and extrafollicular peripheral B-cell responses. We further examine the complex role of Toll-like receptors (TLRs) in humoral autoimmunity, pointing out potential crosstalk between BLyS and TLR pathways. Drug Dev Res 72:779-787, 2011.

• 出版日期2011-12