A ketogenic diet does not impair rat behavior or long-term potentiation

作者：Thio Liu Lin^*; Rensing Nicholas; Maloney Susan; Wozniak David F; Xiong Chengjie; Yamada Kelvin A

来源：Epilepsia, 2010, 51(8): 1619-1623.

DOI：10.1111/j.1528-1167.2009.02515.x

• Calorie-restricted
• Conditioned fear test
• Locomotor activity
• Medial perforant path
• Paired-pulse modulation

P>The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically. We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie-restricted diet (CR) for 2-3 weeks. CR controlled for the slower weight gain experienced by KD-fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired-pulse modulation (PPM) and long-term potentiation (LTP) in the medial perforant path in vivo. KD-fed rats performed similarly to SD-fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity.

• 出版日期2010-8