Genetics of Mechanosensation in the Heart

作者：Buyandelger Byambajav; Ng Keat Eng; Miocic Snjezana; Gunkel Sylvia; Piotrowska Izabela; Ku Ching Hsin; Knoell Ralph

来源：Journal of Cardiovascular Translational Research, 2011, 4(3): 238-244.

DOI：10.1007/s12265-011-9262-6

• Heart failure
• Cardiomyopathy
• Genetics
• Mechanosensation

Mechanosensation (the ultimate conversion of a mechanical stimulus into a biochemical signal) as well as mechanotransduction (transmission of mechanically induced signals) belong to the most fundamental processes in biology. These effects, because of their dynamic nature, are particularly important for the cardiovascular system. Therefore, it is not surprising that defects in cardiac mechanosensation, are associated with various types of cardiomyopathy and heart failure. However, our current knowledge regarding the genetic basis of impaired mechanosensation in the cardiovascular system is beginning to shed light on this subject and is at the centre of this brief review.

• 出版日期2011-6