Protein-kinase C: its role in activity-dependent Purkinje cell dendritic development and plasticity

作者：Metzger F^*; Kapfhammer JP

来源：Cerebellum, 2003, 2(3): 206-214.

DOI：10.1080/14734220310016150

• Purkinje cell dendrites
• cerebellar plasticity
• dendrite growth
• dendritic growth
• conventional PKC
• classical PKC

The cerebellum is a central organ in the control of motor learning and performance. In this respect, the cellular plasticity model systems of multiple climbing fiber elimination and long-term depression have been intensively studied. The signalling pathways involved in these plastic changes are now well understood on a molecular level and protein kinase C (PKC) activity appears to be crucially involved in both processes. Furthermore, as shown in recent studies, Purkinje cell dendritic development also critically depends on the activity of PKC. Thereby, the Ca2+-dependent PKC subtypes, activated by synaptic inputs through metabotropic glutamate receptors, trigger functional changes as well as long-term anatomical maturation of the Purkinje cell dendritic tree during cerebellar development at different time levels. This review summarizes these findings and forwards the hypothesis of a link between the functional mechanisms underlying LTD and the differentiation of Purkinje cell dendrites.

• 出版日期2003