A practical and expeditious method for the preparation of the potential anticancer agent 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b ':7,8-b '':10,11-b ''']tetraindole (CTet)

作者：Lucarini Simone; Antonietti Francesca; Tontini Andrea; Mestichelli Paola; Magnani Mauro; Duranti Andrea^*

来源：Tetrahedron Letters, 2011, 52(22): 2812-2814.

DOI：10.1016/j.tetlet.2011.03.117

• Indole-3-carbinol
• Indole cyclic tetramer
• One-pot reaction
• Breast cancer

A new synthetic method to obtain the potential anticancer agent 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-6:4,5-b':7,8-b '':10,11-b''']tetraindole ((let), starting from 1H-indole-3-carboxaldehyde and sulfamide, is described. Although a mixture of CTet and cyclic indole trimer (CTr) is formed, higher CTet/CTr ratio (4:6) and Cret yield (15%) make our protocol more favorable than those reported in the literature. A discussion on the possible reaction mechanism is reported.

• 出版日期2011-6-1