A comparison of neuropsychological performance between US and Russia: Preparing for a global clinical trial

作者：Hayden Kathleen M^*; Makeeva Oksana A; Newby L Kristin; Plassman Brenda L; Markova Valentina V; Dunham Ashley; Romero Heather R; Melikyan Zarui A; Germain Cassandra M; Welsh Bohmer Kathleen A; Roses Allen D

来源：Alzheimer's and Dementia, 2014, 10(6): 760-768.

DOI：10.1016/j.jalz.2014.02.008

• Cross-cultural comparison
• Neuropsychological tests
• Alzheimer's disease
• Primary prevention delay of onset of MCI due to Alzheimer's disease

Background: Understanding regional differences in cognitive performance is important for interpretation of data from large multinational clinical trials.
Methods: Data from Durham and Cabarrus Counties in North Carolina, USA and Tomsk, Russia (n = 2972) were evaluated. The Montreal Cognitive Assessment (MoCA), Trail Making Test Part B (Trails B), Consortium to Establish a Registry for Alzheimer's Disease Word List Memory Test (WLM) delayed recall, and self-report Alzheimer's Disease Cooperative Studies Mail-In Cognitive Function Screening Instrument (MCFSI) were administered at each site. Multilevel modeling measured the variance explained by site and predictors of cognitive performance.
Results: Site differences accounted for 11% of the variation in the MoCA, 1.6% in Trails B, 1.7% in WLM, and 0.8% in MCFSI scores. Prior memory testing was significantly associated with WLM. Diabetes and stroke were significantly associated with Trails B and MCFSI.
Conclusions: Sources of variation include cultural differences, health conditions, and exposure to test stimuli. Findings highlight the importance of local norms to interpret test performance.

• 出版日期2014-11