A Cu(I)-promoted one-pot 'SNAr-click reaction' of fluoronitrobenzenes

作者：Dururgkar Kulbhushan A; Gonnade Rajesh G; Ramana C V^*

来源：Tetrahedron, 2009, 65(20): 3974-3979.

DOI：10.1016/j.tet.2009.03.035

A one-pot two-step sequence involving a nucleophilic aromatic substitution (SNAF) of activated fluorobenzenes with azide nucleophile and in situ Huisgen cycloaddition of the resulting aryl azides with alkynes has been developed for a rapid access to 1,4-substituted triazoles. Control experiments revealed that both the steps are catalyzed by Cu(I) and also the course of reaction as SNAr followed by [3 2]-cycloaddition.

• 出版日期2009-5-16