Achieving broad molecular insights into dynamic protein interactions by integrated structural-kinetic approaches

作者：Grossman Moran; Sela Passwell Netta; Sagi Irit^*

来源：Current Opinion in Structural Biology, 2011, 21(5): 678-685.

DOI：10.1016/j.sbi.2011.07.008

A network of dynamic protein interactions with their protein partners, substrates, and ligands is known to be crucial for biological function. Revealing molecular and structural-based mechanisms at atomic resolution and in real-time is fundamental for achieving a basic understanding of cellular processes. These technically challenging goals may be achieved by combining time-resolved spectroscopic and structural-kinetic tools, thus providing broad insights into specific molecular events over a wide range of timescales. Here we review representative studies utilizing such an integrated real-time structural approach designed to reveal molecular mechanisms underlying protein interactions at atomic resolution.

• 出版日期2011-10