DTBP/TBHP-Promoted Hydroacylation of Unactivated Alkenes

作者：Jhuang Huei Shu; Reddy Daggula Mallikarjuna; Chen Te Hsuan; Lee Chin Fa

来源：Asian Journal of Organic Chemistry, 2016, 5(12): 1452-1456.

DOI：10.1002/ajoc.201600423

<jats:title>Abstract</jats:title><jats:p>Di‐<jats:italic>tert</jats:italic>‐butyl peroxide (DTBP)‐promoted intermolecular hydroacylation reaction of alkenes with aromatic aldehydes that provides ketones is described. In this study, 4‐chromanones were formed when 2‐(allyloxy)benzaldehydes were treated with <jats:italic>tert</jats:italic>‐butyl hydroperoxide (TBHP). The reactions were performed under solvent‐ and metal‐free conditions. Reactions proceeded through the generation of acyl radicals, followed by the reaction with alkenes. Remarkably, not only terminal alkenes but also internal alkenes could serve as the starting materials for intramolecular hydroacylation reaction.</jats:p>

• 出版日期2016-12