A review of syntheses of 1,5-disubstituted tetrazole derivatives

作者：Sarvary Afshin; Maleki Ali^*

来源：Molecular Diversity, 2015, 19(1): 189-212.

DOI：10.1007/s11030-014-9553-3

• Tetrazole
• Heterocycle
• Nitrile
• Azide
• Amide
• Heterocumulene

This report provides a brief overview of the various representative literature procedures for the synthesis of 1,5-disubstituted tetrazoles (1,5-DSTs) and fused 1,5-disubstituted tetrazoles with more than 120 references. Most of the published methods for the synthesis of 1,5-DSTs include the use of nitriles, amides, thioamides, imidoyl chlorides, heterocumulenes, isocyanates, isothiocyanates, carbodiimides, ketenimines, ketones, amines, and alkenes as the starting materials. The transformation of 1- and 5-substituted tetrazoles into 1,5-DSTs is also covered in this report.

• 出版日期2015-2