Anti-inflammatory and Antimalarial Meroterpenoids from the New Zealand Ascidian Aplidium scabellum

作者：Chan Susanna T S; Pearce A Norrie; Januario Ana H; Page Michael J; Kaiser Marcel; McLaughlin Rene J; Harper Jacquie L; Webb Victoria L; Barker David; Copp Brent R^*

来源：Journal of Organic Chemistry, 2011, 76(21): 9151-9156.

DOI：10.1021/jo201654h

Bioassay-directed fractionation of an extract of the New Zealand ascidian Aplidium scabellum has afforded the anti-inflammatory secondary metabolite 2-geranyl-6-methoxy-1,4-hydroquinone-4-sulfate (1) and a family of pseudodimeric meroterpenoids scabellones A (2) D (5). The benzo[c]chromene-7,10-dione scaffold contained within scabellones A D is particularly rare among natural products. The structures were elucidated by interpretation of NMR data. Scabellone B was also identified as a moderately potent, nontoxic inhibitor of Plasmodium falciparum.

• 出版日期2011-11-4
• 单位河北医科大学