Acid-Degradable Cationic Dextran Particles for the Delivery of siRNA Therapeutics

作者：Cohen Jessica L; Schubert Stephanie; Wich Peter R; Cui Lina; Cohen Joel A; Mynar Justin L; Frechet Jean M J^*

来源：Bioconjugate Chemistry, 2011, 22(6): 1056-1065.

DOI：10.1021/bc100542r

We report a new acid-sensitive, biocompatible, and biodegradable microparticulate delivery system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to efficiently encapsulate siRNA. These particles demonstrated efficient gene knockdown in HeLa-luc cells with minimal toxicity. This knockdown was comparable to that obtained using Lipofectamine, a commercially available transfection reagent generally limited to in vitro use due to its high toxicity.

• 出版日期2011-6