Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity

作者:Simon Levert Annabel; Menniti Christophe; Soulere Laurent; Geneviere Anne Marie; Barthomeuf Chantal; Banaigs Bernard*; Witczak Anne
来源:Marine Drugs, 2010, 8(2): 347-358.
DOI:10.3390/md8020347

摘要

Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.

  • 出版日期2010-2