An antioxidant-like action for non-peroxidisable phospholipids using ferrous iron as a peroxidation initiator

作者：Cortie Colin H^*; Else Paul L

来源：Biochimica et Biophysica Acta-Biomembranes, 2015, 1848(6): 1303-1307.

DOI：10.1016/j.bbamem.2015.03.002

• Fatty acids
• Peroxidation
• Membrane
• Liposomes
• Ferrous iron

The degradation of phospholipids containing polyunsaturated fatty acids, termed peroxidation, poses a constant challenge to membranes lipid composition and function. Phospholipids with saturated (e.g. PC 16:0/16:0) and monounsaturated fatty acids (e.g. PC 16:0/18:1) are some of the most common phospholipids found in membranes and are generally not peroxidisable. The present experiments show that these non-peroxidisable phospholipids, when present in liposomes with peroxidisable phospholipids (i.e. those containing polyunsaturated fatty acids) such as PC 16:0/18:2 and Soy PC, produce an inhibitory effect on rates of peroxidation induced by ferrous-iron. This inhibitory effect acts to extend the duration of the lag phase by several-fold. If present in natural systems, this action could enhance the capacity of conventional antioxidant mechanisms in membranes. The results of this preliminary work suggest that non-peroxidisable phospholipids may exert an antioxidant-like action in membranes.

• 出版日期2015-6