Antimicrobial Activity of the Marine Alkaloids, Clathrodin and Oroidin, and Their Synthetic Analogues

作者：Zidar Nace; Montalvao Sofia; Hodnik Ziga; Nawrot Dorota A; Zula Ales; Ilas Janez; Kikelj Danijel; Tammela Paivi^*; Masic Lucija Peterlin

来源：Marine Drugs, 2014, 12(2): 940-963.

DOI：10.3390/md12020940

• marine alkaloid
• Agelas
• antimicrobial
• antibacterial
• antifungal
• pyrrole-2-aminoimidazole
• oroidin
• clathrodin

ATCC, American Type Culture Collection; d, doublet; dd, doublet of doublets; ddd, doublet of doublet of doublets; DMF, N,N-dimethylformamide; DMSO, dimethylsulfoxide; dt, doublet of triplets; ESI, electrospray ionization; EtOH, ethanol; FT-IR, fourier transform infrared; HRMS, high resolution mass spectrometry; Huh-7, human hepatocellular carcinoma cell line; IR, infrared; MOPS, 3-(N-morpholino)propanesulfonic acid; mp, melting point; NMM, N-methylmorpholine; R, radical; RPMI-1640, Roswell Park Memorial Institute medium 1640; rt, room temperature; s, singlet; TBTU, N,N,N',N'-tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate; td, triplet of doublets; THF, tetrahydrofuran; TLC, thin layer chromatography; TMS, tetramethylsilane; Vis, visible light.

• 出版日期2014-2