Approach to the Treatment-Experienced Patient with Hepatitis C Virus Genotype 1 Infection

作者：Flemming Jennifer A; Terrault Norah A^*

来源：Infectious Disease Clinics of North America, 2012, 26(4): 903-+.

DOI：10.1016/j.idc.2012.08.008

• Protease inhibitor
• Hepatitis C
• Antiviral
• Treatment-experienced
• Relapser
• Partial responder
• Null responder
• Systemic vascular resistance

A significant proportion of treatment-experienced hepatitis C virus genotype 1 (GT1) patients will not achieve systemic vascular resistance with protease inhibitor-triple therapy, and so the need for alternative therapies for these patients remains high. The aim of this article is to provide a critical evaluation of the available data, highlighting the knowledge gaps and providing a practical framework for making treatment decisions in treatment-experienced GT1 patients with currently approved drugs.

• 出版日期2012-12