Nimesulide May Be More Efficient Than Allopurinol in Protecting Pancreas From Acute Ischemia/Reperfusion Injury in an Animal Model

作者：Apostolidis Dimosthenis; Ntinas Achilleas^*; Kardassis Dimitrios; Koulouris Nikolaos; Thomareis Olympia; Karayannopoulou Georgia; Vrochides Dionisios

来源：Vascular and Endovascular Surgery, 2012, 46(8): 654-663.

DOI：10.1177/1538574412465478

• allopurinol
• nimesulide
• pancreatic I/R injury

Objective: To determine the influence of allopurinol and nimesulide in the protection of the pancreas from acute ischemia-reperfusion (I/R) injury. Materials and Methods: A total of 30 rabbits were divided into 3 groups, group A: acute I/R only; group B: allopurinol (30 mg/kg) was administered intravenously 10 minutes before ischemia; group C: nimesulide (50 mg/kg) was given intraperitoneally 20 minutes before ischemia. Neopterin and superoxide dismutase (SOD) levels were examined. Pancreatic biopsies were obtained for electron microscopy study. Results: The mean neopterin concentrations in group A are 3.56 +/- 3.41, 7.74 +/- 3.59, and 8.94 +/- 2.86 ng/mL, respectively, in the stabilization, ischemia, and reperfusion phases; group B: 3.40 +/- 3.03, 7.45 +/- 8.89, and 10.64 +/- 7.47 ng/mL; and group C: 3.41 +/- 2.71, 5.67 +/- 2.76, and 4.34 +/- 2.87 ng/mL. The mean SOD concentrations in group A are 4.25 +/- 1.79, 4.48 +/- 1.60, and 5.57 +/- 1.15 ng/mL; group B: 4.32 +/- 0.81, 5.08 +/- 1.10, and 4.45 +/- 1.31 ng/mL; and group C: 4.10 +/- 0.99, 5.23 +/- 1.60, and 3.72 +/- 1.30 ng/mL. Histopathology showed the least deterioration in group C. Conclusion: Nimesulide is more efficient than allopurinol in protecting pancreas from acute I/R injury.

• 出版日期2012-11