Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii

作者：Hwang Byung Soon; Lee In Kyoung; Choi Hwa Jung; Yun Bong Sik^*

来源：Bioorganic & Medicinal Chemistry Letters, 2015, 25(16): 3256-3260.

DOI：10.1016/j.bmcl.2015.05.081

• Phellinus baumii
• Polyphenol
• Neuraminidase inhibition
• Anti-influenza
• Cytopathic effect

Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.

• 出版日期2015-8-15