Association between IL-10 genetic variations and cervical cancer susceptibility in a Chinese population

作者：Bai, C. Y.; Shi, X. Y.^*; He, J.; Xue, J.; Feng, Y.

来源：Genetics and Molecular Research, 2016, 15(3): 15038116.

DOI：10.4238/gmr.15038116

• Interleukin-10
• Polymorphism
• Cervical cancer

We conducted an investigation into the role of the IL-10 polymorphisms -592A/C (rs1800872), -819C/T (rs1800871), and -1082A/G (rs1800896) in cervical cancer risk in a Chinese population. A case-control study was carried out, including 165 newly diagnosed cervical cancer patients and 165 control subjects. The polymerase chain reaction-restriction fragment length polymorphism method was used to genotype the three IL-10 variant loci. Using conditional logistic regression analysis, we observed that homozygous IL-10 -819C/T TT carriers were at significantly increased risk of cervical cancer compared to homozygous CC individuals, with an adjusted odds ratio (OR) of 2.23 and a 95% confidence interval (CI) of 1.16-4.30. Moreover, the CT+TT genotype was significantly associated with cervical cancer in comparison to the wild-type variant (OR = 1.69, 95% CI = 1.04-2.76; P = 0.03). In conclusion, our study suggests that the IL-10 -819C/T genetic variation may contribute to cervical cancer risk in the Chinese population examined.

• 出版日期2016
• 单位延安大学