BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins

作者:Rodriguez Cristina; de Gonzalo Gonzalo; Rioz Martinez Ana; Pazmino Daniel E Torres; Fraaije Marco W; Gotor Vicente*
来源:Organic and Biomolecular Chemistry, 2010, 8(5): 1121-1125.
DOI:10.1039/b922693a

摘要

4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB was employed in the presence of a weak anion exchange resin to perform dynamic kinetic resolutions of racemic benzyl ketones with high conversions and good optical purities. Different parameters that affect to the efficiency of the enzymatic Baeyer-Villiger oxidation and racemisation were analyzed in order to optimize the activity and selectivity of the biocatalytic system.

  • 出版日期2010