alpha-Chitin nanofibrils improve inflammatory and fibrosis responses in inflammatory bowel disease mice model

作者：Azuma Kazuo; Osaki Tomohiro^*; Ifuku Shinsuke; Saimoto Hiroyuki; Tsuka Takeshi; Imagawa Tomohiro; Okamoto Yoshiharu; Minami Saburo

来源：Carbohydrate Polymers, 2012, 90(1): 197-200.

DOI：10.1016/j.carbpol.2012.05.023

• alpha-Chitin nanofibrils
• Inflammatory bowel disease
• Nuclear factor kappa B
• Anti-inflammatory
• Anti-fibrosis

We evaluated the anti-inflammatory and anti-fibrosis effects of alpha-chitin nanofibrils in a mouse model of dextran sulfate sodium (DSS)-induced acute ulcerative colitis (UC). alpha-Chitin nanofibrils decreased positive areas of nuclear factor-kappa B staining in the colon tissue (7.2 +/- 0.5%/fields in the alpha-chitin nanofibrils group vs. 10.7 +/- 0.9%/fields in the control group; p %26lt; 0.05). alpha-Chitin nanofibrils also decreased serum monocyte chemotactic protein-1 concentration in DSS-induced acute UC (24.1 +/- 7.8 pg/ml in the alpha-chitin nanofibrils group vs. 53.5 +/- 3.1 pg/ml in the control group; p %26lt; 0.05). Moreover, alpha-chitin nanofibrils suppressed the increased positive areas of Masson%26apos;s trichrome staining in colon tissue (6.8 +/- 0.6%/fields in the alpha-chitin nanofibrils group vs. 10.1 +/- 0.7%/fields in the control group; p %26lt; 0.05). On the other hand, alpha-chitin powder suspension did not show these effects in DSS-induced acute UC mice model. Our results indicated that alpha-chitin nanofibrils have the anti-inflammatory effect via suppressing NF-kappa B activation and the anti-fibrosis effects in DSS-induced acute UC mice model.

• 出版日期2012-9-1