Application of a Ball Milling Technique for the Condensation of Anthranilic Hydrazides with Aromatic Aldehydes Towards 4-Quinazolinone Derivatives

作者：Magyar T; Miklos F; Lazar L; Fueloep F^*

来源：Chemistry of Heterocyclic Compounds, 2015, 50(10): 1464-1470.

DOI：10.1007/s10593-014-1611-3

• hydrazides
• quinazolinones
• ball milling reactions
• mechanochemistry
• solventless reactions

An environmentally friendly method was applied to prepare anthranilic hydrazones and quinazolin-4(1H)-ones from anthranilic hydrazides and a number of aldehydes in solventless medium. The condensations proceeded smoothly under ball milling conditions at room temperature, and the products were obtained in high purity and yield.

• 出版日期2015-1