Arterial Spin Labeling MRI: A step forward in non-invasive delineation of focal cortical dysplasia in children

作者：Blauwblomme Thomas^*; Boddaert Nathalie; Chemaly Nicole; Chiron Catherine; Pages Melanie; Varlet Pascale; Bourgeois Marie; Bahi Buisson Nadia; Kaminska Anna; Grevent David; Brunelle Francis; Sainte Rose Christian; Archambaud Frederique; Nabbout Rima

来源：Epilepsy Research, 2014, 108(10): 1932-1939.

DOI：10.1016/j.eplepsyres.2014.09.029

• Arterial Spin Labeling
• FDG-PET
• Focal cortical dysplasia
• Epilepsy surgery

The aim was to localize the interictal cerebral perfusion abnormalities of focal cortical dysplasia (FCD) in children with Arterial Spin Labeling MRI (ASL) in a retrospective study of nine consecutive children explored with multimodal investigation during interictal periods. We analyzed brain morphology with a 1.5T MRI and a dedicated protocol for epilepsy. Brain perfusion was quantified with pseudo continuous ASL. Brain metabolism was imaged with (18)FDG-PET in six patients. Microvessel histology was studied in five children who underwent epilepsy surgery with CD34 immunostaining on FCD and control samples. Localized decrease of cerebral blood flow (CBF) was found on visual analysis in all patients with ASL. It was co-localized with the structural MRI abnormalities in every case, with PET hypo-metabolism in 5/6 cases, and with histologically proven FCD type lib in 5/5 cases (all seizure free after surgery). CBF was lower (Kruskal-Wallis test, p = 0.001) in FCD than in normal cortex. The total count of CD34+ microvessels was similar in FCD and control cases, but microvasculature showed disorganized architecture. Interictal ASL is a non-invasive method that may help to localize the epileptogenic zone showing hypo-perfusion in FCD. Whether this finding could be generalized to MRI-negative FCD needs to be further studied.

• 出版日期2014-12
• 单位中国地震局