Acidity-triggered surface charge neutralization and aggregation of functionalized nanoparticles for promoted tumor uptake

作者：Yu Ting Wei; Lu I Lin; Huang Wen Chia; Hu Shang Hsiu; Hung Chia Chian; Chiang Wen Hsuan^*; Chiu Hsin Cheng^*

来源：RSC Advances, 2016, 6(43): 36293-36295.

DOI：10.1039/c6ra05807h

A polymeric nanovehicle featuring a histidine-rich surface was developed for tumor-targeted delivery of doxorubicin. By tumor acidity-triggered surface charge neutralization and aggregation of drug-carrying nanoparticles, the drug accumulation within the tumor was significantly enhanced.

• 出版日期2016
• 单位清华大学