Activity-based probes as molecular tools for biomarker discovery

作者:Carvalho L A R; Ruivo E F P; Lucas S D; Moreira R*
来源:Medchemcomm, 2015, 6(4): 536-546.
DOI:10.1039/c4md00417e

摘要

Biomarker discovery and validation techniques have been extensively developed together with the "omics" era. Nevertheless, there is still a reduced number of biomarker candidates that surpass clinical trials every year. One of the drawbacks of biomarker discovery deals with the quantification of disease-related entities and its correlation with disease predisposition, disease stages or treatment response. Thus, activity-based profiling emerges as an exceptional tool for biomarker discovery and validation and this review highlights advances in this field.