Alternative synthesis of (-)-Geissman-Waiss lactone, a key intermediate of necine bases

作者：Honda T^*; Matsumoto S

来源：Heterocycles, 2005, 66(1): 341-346.

DOI：10.3987/com-05-s(k)29

• ring-closing metathesis
• intramolecular Michael reaction
• pyrrolizidine alkaloid
• anti-malarial piperidine alkaloid

A facile synthetic route to (-)-Geissman-Waiss lactone, a key intermediate of necine bases, was established by employing ring closing metathesis (RCM), followed by intramolecular Michael reaction of the resulting a,p-unsaturated lactone, as the key steps.

• 出版日期2005-12-31