Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunistic fungi

作者：Regasini Luis Octavio^*; Pivatto Marcos; Scorzoni Liliana; Benaducci Tatiane; Fusco Almeida Ana Marisa; Soares Mendes Giannini Maria Jose; Barreiro Eliezer Jesus; Siqueira Siva Dulce Helena; Bolzani Vanderlan da Silva

来源：Brazilian Journal of Pharmacognosy, 2010, 20(5): 706-711.

DOI：10.1590/S0102-695X2010005000017

• Pterogyne nitens
• guanidine alkaloids
• antifungal
• opportunistic fungi
• Candida spp.
• Cryptococcus neoformans

As part of our ongoing research on antifungal agents from Brazilian flora, eight extracts and twelve fractions from Pterogyne nitens Tul., Fabaceae, were screened for antimicrobial activity against four opportunistic fungi species (Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans) using a broth microdilution method. The present investigation reveals that P. nitens extracts and fractions were more effective against C. krusei and C. parapsilosis than against C. neoformans. The growth of C. albicans was moderately affected by all tested extracts and fractions. The strongest effects were observed for n-butanol fractions from branches (MIC = 15.6 mu g/mL) and roots (MIC = 31.2 mu g/mL) against C. krusei. Additionally, the chromatographic fractionation of the n-butanol fraction from branches afforded four guanidine alkaloids; N-1, N-2, N-3-triisopentenylguanidine (1), described for the first time in the Fabaceae family, and nitensidines A-C (2-4), which showed moderate activity towards C. krusei (MIC = 62.5 mu g/mL) and C. parapsilosis (MIC = 31.2 mu g/mL).

• 出版日期2010-11