Desflurane Attenuates Ventilator-Induced Lung Injury in Rats with Acute Respiratory Distress Syndrome

作者：Lin, Xue; Ju, Ying-nan; Gao, Wei; Li, Dong-mei; Guo, Chang-chun^*

来源：Biomed Research International, 2018, 2018: 7507314.

DOI：10.1155/2018/7507314

• FACTOR-KAPPA-B
• MECHANICAL VENTILATION
• INFLAMMATORY RESPONSE
• ISOFLURANE
• CYTOKINES
• VOLATILE
• SEVOFLURANE
• ANESTHESIA
• MODEL
• OXYGENATION

Ventilator-induced lung injury aggravates the existing lung injury. This study investigated the effect of desflurane on VILI in a rat model of acute respiratory distress syndrome. Forty-eight rats were randomized into a sham (S) group, control (C) group, lipopolysaccharide/ventilation (LV) group, lipopolysaccharide/ventilation/desflurane (LVD) group, or lipopolysaccharide/low ventilation with and without desflurane (LLV and LLVD) groups. Rats in the S group received anesthesia only. Rats in the LV and LVD groups received lipopolysaccharide and were ventilated with a high tidal volume. Rats in LLV and LLVD groups were treated as the LV and LVD groups and ventilated with a low tidal volume. PaO2 /FiO(2), lung wet-to-dry weight ratios, concentrations of inflammatory factors in serum and BALF, histopathologic analysis of lung tissue, and levels of nuclear factor-(NF-) kappa B protein in lung tissue were investigated. PaO2 /FiO(2) was significantly increased by desflurane. Total cell count, macrophages, and neutrophils in BALF and proinflammatory factors in BALF and serum were significantly decreased by desflurane, while IL-10 was increased. The histopathological changes and levels of NF-kappa B protein in lung tissue were decreased by desflurane. The results indicated that desflurane ameliorated VILI in a rat model of acute respiratory distress syndrome.

• 出版日期2018
• 单位哈尔滨医科大学