Anti-biofilm Activity of Xanthorrhizol Isolated from Curcuma xanthorrhiza Roxb. against Bacterial Biofilms Formed by Saliva and Artificial Multi-species Oral Strains

作者：Yanti; Rukayadi Yaya; Lee Kwanhyoung; Han Sunghwa; Hwang Jae Kwan^*

来源：Food Science and Biotechnology, 2009, 18(2): 556-560.

• anti-biofilm activity
• Curcuma xanthorrhiza Roxb.
• xanthorrhizol
• oral biofilm

Xanthorrhizol, a sesquiterpene isolated from Curcuma xanthorrhiza Roxb., Was used to investigate its effect on reducing the saliva and in multi-species oral biofilms consisting of Streptococcus mutans, Streptococcus sanguis, and Actinomyces viscosus by anti-biofilm and confocal laser scanning microscopy (CLSM) assays. Xanthorrhizol exhibited significant anti-biofilm activity in the dose- and time-dependent manners. Exposure to 2 and 5 mu g/mL xanthorrhizol for 30 ruin remained <50% of saliva and multi-species biofilms formed tor 24 hr. In addition, exposure to 10 mu g/mL xanthorrhizol for 30 min reduced 65 and 77% of 24 hr saliva and multi-species oral biofilms, respectively. CLSM results visually demonstrated that xanthorrhizol reduced bacterial viability, in the saliva and multi-species oral biofilms. These results suggest that C. xanthorrhiza Roxb. containing xanthorrhizol with strong, anti-biofilm activity can be employed as a plant Source for oral care functional foods.

• 出版日期2009-4