First trimester biochemistry at different maternal ages

作者：Ranta Jenni K; Marttala Jaana; Laitinen Paivi; Kultti Johanna; Kauhanen Olavi; Romppanen Jarkko; Hamalainen Esa; Heinonen Seppo; Pulkki Kari; Ryynanen Markku^*

来源：Clinical Chemistry and Laboratory Medicine, 2012, 50(3): 549-555.

DOI：10.1515/CCLM.2011.785

• Down syndrome
• first trimester
• free beta-hCG
• gestational age
• maternal age
• PAPP-A
• screening

Background: The performance of first trimester biochemical screening was compared at different pregnancy weeks and maternal ages during 2002-2008 in a screened population of 76,949 women. %26lt;br%26gt;Methods: The detection rates, as well as the median multiples of a median (MOMs) of free beta-human chorionic gonadotropin (free beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A), were compared between completed gestational weeks 8-13 and between different maternal ages separated into 5-year groupings. %26lt;br%26gt;Results: The number of singleton Down syndrome pregnancies was 221. The median age of the screened women was 30 years and the proportion of women aged %26gt;= 35 years 16.9%. The median age of the women with a Down syndrome pregnancy was 37 years. In women aged %26lt;35 years, the biochemical markers provided a detection rate of only 38.6%, whereas in women aged %26gt;= 35 years, the biochemical markers detected 82.7% of cases (p%26lt;0.01). %26lt;br%26gt;Conclusions: Biochemical screening works best amongst women aged %26gt;= 35 years. For younger mothers aged %26lt;35 years, combined screening should be the method of choice.

• 出版日期2012