ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF METHANOL EXTRACTS AND ALKALOID FRACTIONS OF FOUR MEXICAN MEDICINAL PLANTS OF SOLANACEAE

作者：Gutierrez A Dora M; Bah Moustapha; Garduno R Maria L; Mendoza D Sandra O; Serrano C Valentina

来源：African Journal of Traditional, Complementary and Alternative Medicines, 2014, 11(3): 259-267.

DOI：10.4314/ajtcam.v11i3.36

• Solanaceae family
• antioxidant activity
• anti-inflammatory activity

Background: Methanol extracts and alkaloid fractions of different parts of four plant species belonging to Solanaceae family and used in Mexican traditional medicine were investigated for their total phenolic contents, anti-inflammatory and antioxidant properties.
Materials and Methods: The total phenolic compounds of each extract was determined according to the Folin-Ciocalteu method, while the in vitro radical scavenging activities of the extracts were assessed using the DPPH and ABTS radicals. The in vivo anti-inflammatory activity was determined using the TPA-induced mouse ear edema model.
Results: The methanol extracts contained the highest concentrations of phenolic compounds and also exhibited the best reducing power on the DPPH and ABTS radicals, in a concentration-dependent fashion. However, the anti-inflammatory activity did not follow the same trend, as some alkaloid fractions that showed low radical reducing power exhibited the strongest anti-inflammatory activity.
Conclusion: The methanol extract obtained from the flowers of Nicotiana glauca presented the best overall performance with the largest amount of phenolic compounds (111 mu g garlic acid equivalents/g of extract), the best antioxidant activity (94.80% inhibition of DPPH and 97.57% of ABTS) and the highest anti-inflammatory activity (81.93% inhibition of the inflammation).

• 出版日期2014