Activation and Deactivation of 5-HT1 Receptor of Accumbens Shell Area does not Alter ACPA-induced Aversive Memory Deficit in Male Rat

作者：Keramati Nojedehsadat Marzieh; Oryan Shahrbanoo; Zarrindast Mohammad Reza^*; Babapour Vahab

来源：Archives of Iranian Medicine, 2017, 20(3): 185-192.

• Accumbens shell
• ACPA
• aversive memory
• 5-HT1 receptors agonist and antagonist

Background: Some studies have indicated a close relation between serotonergic and cannabino dergic systems in several brain regions. Thus, the aim of current study is investigating the effect of 5-HT1 receptors of accumbens shell (Acb shell) on aversive memory deficit induced by ACPA (cannabinoid CB1 receptor agonist) using test-retest protocol of elevated plus-maze (EPM) in male VVistar rats.
Method: Bilateral guide cannulae were implanted to allow microinjection of AC PA, CP94253 HCL (5-HT1 receptor agonist agonist) or GR127935 HCL (5-HT1 receptor antagonist).
Results: Post-test intra-Acb shell of ACPA (0.002 pg/rat), CP94253 (0.5 and 5 ng/rat) and GR127935 (5 ng/rat) increased the percentage of open-arms time (%OAT) in the EPM task compared to the control group, indicating aversive memory deficit. Moreover, concurrent microinjection of the subthreshold dose of CP94253 and GR127935 into Acb shell did not alter open-arms exploratory behavior induced by intra-Acb shell of ACPA on the retest day.
Conclusion: Our data suggests that Acb shell 5-HT1 receptor does not affect aversive memory deficit induced by ACPA in the Acb shell.

• 出版日期2017-3