Apigenin stabilized gold nanoparticles increased radiation therapy efficiency in lung cancer cells

作者：Jiang, Jing; Mao, Qishan; Li, Hang; Lou, Jingqiu^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(9): 13298-13305.

• Apigenin
• gold nanoparticles (AuNPs)
• chemotherapy
• radiation therapy
• lung cancer

One of the recent trends in cancer treatment is the combination of different therapies (i.e. chemotherapy, radiation or immunotherapy etc.). This work described a combination of chemotherapy and enhanced radiotherapy for in vitro treatment of lung cancer by using gold nanoparticles stabilized by apigenin-a bioactive gradient that has been investigated for cancer treatments. The gold nanoparticles (AuNPs) were synthesized via reducing gold salts with apigenin, and had an average diameter of 20 nm to 30 nm and a zeta potential of -20 mV. Upon interacting with lung cancer cells, the nanoparticles were able to induce cell apoptosis, inhibit cell proliferation and arrest cancer cells in G0/G1 phases in a dose dependent manner. When using X-rays and the nanoparticles together, an additive anti-cancer effect was generated from chemotherapeutic functions of apigenin and the enhanced radiation killing effect produced by nanoparticles & X-ray interactions. This study may provide a promising therapeutic strategy for cancer treatment which integrates the advantages of both radiation and chemotherapies.

• 出版日期2017
• 单位青岛大学; 烟台毓璜顶医院