Antithyroid drugs and congenital malformations

作者:Korevaar Tim I M*; Peeters Robin P
来源:Nature Reviews Endocrinology, 2018, 14(6): 328-329.
DOI:10.1038/s41574-018-0012-6

摘要

A new study showed that propylthiouracil and methimazole use during pregnancy was associated with increased risk of congenital malformations. Intriguingly, the authors identified dose-dependent effects for methimazole but not propylthiouracil, whereas the recommended switch from methimazole to propylthiouracil during early pregnancy did not reduce the risk of congenital malformations.

  • 出版日期2018-6

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