摘要
A versatile and broad range approach to previously unknown bis(indolyl)methane oximes based on two consecutive hetero Diels Alder cycloaddition reactions of electrophilic conjugated nitrosoalkenes with indoles is disclosed. The cytotoxic properties and selectivity of some adducts against several human cancer cell lines pointing to a promising role in the development of anti-tumoural drugs, in particular for leukaemia and lymphoma.
- 出版日期2015-3-26