Acanthamoeba granulomatous amoebic encephalitis after pediatric hematopoietic stem cell transplant

作者：Coven Scott L^*; Song Eunkyung; Steward Sarah; Pierson Christopher R; Cope Jennifer R; Ali Ibne K; Ardura Monica I; Hall Mark W; Chung Melissa G; Bajwa Rajinder P S

来源：Pediatric Transplantation, 2017, 21(8): e13060.

DOI：10.1111/petr.13060

• bone marrow transplantation
• infectious disease
• secondary leukemia

Acanthamoeba encephalitis is a rare, often fatal condition, particularly after HSCT, with 9 reported cases to date in the world literature. Our case was originally diagnosed with ALL at age 3years, and after several relapses underwent HSCT at age 9years. At 17years of age, he was diagnosed with secondary AML for which he underwent a second allogeneic HSCT. He presented with acute-onset worsening neurological deficits on day +226 after the second transplant and a post-mortem diagnosis of Acanthamoeba encephalitis was established, with the aid of the CDC.

• 出版日期2017-12