Vitamin D and respiratory health

作者：Hughes D A^*; Norton R

来源：Clinical and Experimental Immunology, 2009, 158(1): 20-25.

DOI：10.1111/j.1365-2249.2009.04001.x

• inflammation
• immune function
• lung
• vitamin D

P>Vitamin D is now known to be of physiological importance outside of bone health and calcium homeostasis, and there is mounting evidence that it plays a beneficial role in the prevention and/or treatment of a wide range of diseases. In this brief review the known effects of vitamin D on immune function are described in relation to respiratory health. Vitamin D appears capable of inhibiting pulmonary inflammatory responses while enhancing innate defence mechanisms against respiratory pathogens. Population-based studies showing an association between circulating vitamin D levels and lung function provide strong justification for randomized controlled clinical trials of vitamin D supplementation in patients with respiratory diseases to assess both efficacy and optimal dosage.

• 出版日期2009-10