A new diarylheptanoid and a new diarylheptanoid glycoside isolated from the roots of Juglans mandshurica and their anti-inflammatory activities

作者：Diao, Shengbao; Jin, Mei; Sun, Jinfeng; Zhou, Yi; Ye, Chao; Jin, Yong; Zhou, Wei^*; Li, Gao^*

来源：Natural Product Research, 2019, 33(5): 701-707.

DOI：10.1080/14786419.2017.1408100

• Juglans mandshurica
• Juglandaceae
• diarylheptanoids
• NO production
• TNF-alpha production
• IL-6 production

A new diarylheptanoid, (2S,3S,5S)-2,3,5-trihydroxy-1,7-bis(4-hydroxy- 3-methoxyphenyl)heptane (1), and a new diarylheptanoid glycoside, (2S,3S,5S)-2,3-dihydroxy-5-O-beta-d-xylopyranosyl-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)heptane (2), together with three known compounds, rhoiptelol C (3), rhoiptelol B (4) and 3 ',4 ''-epoxy-2-O-beta-d-glucopyanosyl-1-(4-hydroxyphenyl)- 7-(3-methoxyphenyl)heptan-3-one (5) were isolated from the roots of Juglans mandshurica (Juglandaceae). The structures of compounds 1 and 2 were identified based on HR-ESI-MS, 1D and 2D NMR spectroscopic methods. Compounds 1-5 were assayed for their inhibitory effects on the production of NO, TNF-alpha and IL-6 in LPS-stimulated RAW264.7 cells. @@@ [GRAPHICS] @@@ .

• 出版日期2019-3-4
• 单位延边大学