Dimeric Fe-Co Phthalocyanine Complex as a Reagent for the Selective Damage of Nucleic Acids

作者：Chernonosov Alexander A^*; Solov'eva Ludmila I; Luk'yanets Evgenii A; Knorre Dmitrii G; Fedorova Ol'ga S

来源：Macroheterocycles, 2011, 4(2): 135-137.

• Fe-II and Co-II phthalocyanines
• nucleic acid
• catalysis

The complexes of Fe-II and Co-II with phthalocyanines are extremely good catalysts for oxidation of organic compounds with molecular oxygen and hydrogen peroxide. Their solubility and reactivity are increased by conjugation with oligonucleotides and by formation of dimeric complexes between negatively and positively charged phthalocyanines. In our work such complexes were formed directly on single-stranded DNA through interaction between negatively charged Co-II phthalocyanine in conjugate and positively charged Fe-II phthalocyanine in solution. The resulting oppositely charged phthalocyanine complexes showed significant increase of catalytic activity compared with monomeric forms of phthalocyanines Fe-II. The site-directed modification of single- and double-stranded DNA by H2O2 in the presence of dimeric complexes of negatively charged Co-II and positively charged Fe-II phthalocyanines was detected. These complexes catalyzed the DNA oxidation with high efficacy and led to direct DNA strand cleavage.

• 出版日期2011