Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument

作者：Mecklenburg Lars^*; Kusewitt Donna; Kolly Carine; Treumann Silke; Adams E Terence; Diegel Kelly; Yamate Jyoji; Kaufmann Wolfgang; Moller Susanne; Danilenko Dimitry; Bradley Alys

来源：Journal of Toxicologic Pathology, 2013, 26(3): 27S-57S.

DOI：10.1293/tox.26.27S

• diagnostic pathology
• histopathology
• nomenclature
• rodent pathology
• integumentary system
• skin
• rodent

The INHAND (International Harmonization or Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the societies of toxicological pathology from Europe (ESTP), Great Britain (BSTP). Japan (JSTP) and North America (STP). Its aim is to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory rodents. A widely accepted international harmonization of nomenclature in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and will provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists. The purpose of this publication is to provide a standardized nomenclature for classifying microscopical lesions observed in the integument of laboratory rats and mice. Example colour images are provided for most lesions. The standardized nomenclature presented in this document and additional colour images arc also available electronically at http://www.goreni.org. The nomenclature presented herein is based on histopathology databases front government, academia, and industrial laboratories throughout the world, and covers lesions that develop spontaneously as well as those induced by exposure to various test materials.

• 出版日期2013