alpha-Glucosidase inhibitory activity of marine sponges collected in Mauritius waters

作者：Ramanjooloo Avin; Cresteil Thierry; Lebrasse Cindy; Beedessee Girish; Oogarah Preeti; van Soest Rob W M; Marie Daniel E P^*

来源：Natural Product Research, 2015, 29(4): 383-387.

DOI：10.1080/14786419.2014.945173

• alpha-glucosidase
• Mauritius
• marine sponges
• postprandial hyperglycemia

This report describes the use of alpha-glucosidase to evaluate the anti-diabetic potential of extracts from marine sponges collected in the Mauritius waters. Initial screening at 1.0mg/mL of 141 extracts obtained from 47 sponge species revealed 10 extracts with inhibitory activity greater than 85%. Seven of the 10 extracts were further tested at 0.1 and 0.01mg/mL and only the methanol extract of two sponges namely Acanthostylotella sp. (ASSM) and Echinodictyum pykei (EPM) showed inhibition activity greater than 60% at 0.1mg/mL with an IC50 value of 0.16 +/- 0.02 and 0.04 +/- 0.01mg/mL, respectively, while being inactive at 0.01mg/mL.

• 出版日期2015-2-16