科研之友
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摘要
Migu Capsule (MG), an oral Chinese herbal preparation, is made with the water extract of Bushenfang (BSF). BSF is a traditional Chinese herbal formula which was used for prevention and cure degenerative skeletal disease. Prior studies have reported MG could shorten the healing duration of osteoporotic fracture in patients. The present study aimed to investigate the effects of MG on bone healing in a mouse model of osteoporotic fracture. Thirty-six C57BL/6J mice (12 mice in each group) were randomly divided into three groups. Mice in Migu Capsule intervention group (MG group) and ovariectomized control group (OVXC group) received ovariectomy operation. The sham operated control group (SOC group) received a sham operation. Three weeks after the first surgery operation, each mouse withstood right femur osteotomy and internal fixation. SOC and OVXC groups were given 0.9% normal saline which acts as vehicle. MG group were given the mixture of 0.9% normal saline and MG. All the treatments were given via oral gavages once a day for 42 days. Mice were euthanized at a time point of 42 days post femur osteotomy. The results indicated that the SOC and MG groups exhibited a significantly lower mean value of TV than the OVXC group (P < 0.05). As to the vBMD, the SOC and MG groups showed a significantly higher mean value (P < 0.05). Regarding the maximum load, the SOC and MG groups exhibited obviously higher values than the OVXC (P < 0.05). In summary, the results shown here demonstrated that bone healing in a postmenopausal osteoporotic mouse model was significantly improved via treatment with MG as revealed by micro-CT and biomechanical methods. Further studies are needed to clarify the underlying mechanism of action of MG on bone healing.
- 出版日期2017
- 单位上海中医药大学
